HREM-Filters are sophisticated Wiener and Difference filters that extract a periodic feature from the noisy image. Since our filters can use locally-estimated two-dimensional background, they work even for non-ideal crystals, such as a nano-crystal or cylindrical crystal (as shown in the Flier). Furthermore, the iterative filters based on the random noise model for the background effectively reduce the shot noise (random noise/white noise) keeping non-periodic features. This is especially effective for a low-dose (S)TEM image.

Up-sampling
Another feature of HREM-Filters is up-sampling filter. The data acquisition is often performed at a high magnification to obtain good looking images. Using upsampling, the data acquisition can be done at the optimum lower magnification.

Realtime module (the license for Realtime module is required) <Short demo video>
This module performs up-sampling noise filter in live, and reveals the sample structure even from a single frame at extremely low dose.

Read More

Using the up-sampling, you can see a smooth sample structure even when the original image is taken with the sampling interval close to the Nyquist limit. Therefore, this module will accelerate the low-dose experiment in (S)TEM. If the final image size is large, you can select a small area, say 256×256 pixels, for a quick real-time processing.

Example Even at a dose rate as low as 0.25 el/pix/frame, you can observed the sample structure without accumulating the frames. The sample is MOF (Metal Organic Framework), and the image is acquired with a Gatan K2 camera working at Electron Counting mode. (see the Reference below (IMC20) for more details)

<How to experience noise reduction capabilities>
You can check the powerful noise reduction capabilities implemented in the Realtime noise filter by using HREM-Filter Lite (free plug-in). Please experience the power of noise reduction on your own low-dose images at hand.

HREM-Filters Lite (free pulg-in)
When you install the HREM-Filters Lite, you can use some basic features of the <HREM-Filters Pro> free of charge.

Flyer/Specifications

• pdf format

Manual

• HREM Filters (pdf)

Video (mp4)

• Realtime filter demo

References and Technical Notes (*Basic Readings)

• * Real-Time Noise Filter for Extremely Low-Dose Experiments: Microscopy Today 33 May (2025) 28-32 (FREE download)
• Realtime up-sampling noise filter: Paradigm shift for data acquisition, M&M2020 (PDF)
• * Application of Optimum HRTEM Noise Filters in Mineralogy and Related Sciences, Microscopy and Analysis 22, November 2008. (FREE download)
• * Optimal Noise Filters in High-Resolution Electron Microscopy (Microscopy Today 2007 September) (pdf file)
• Optimal Noise Filters in High-Resolution Electron Microscopy (M&M2007) (pdf file)

Examples (Sample Data)

Download

You have to purchase a license (hardware key) to run this program.
Please send your price enquiry to support@hremresearch.com.

• HREM Filters Pro v4.8(Commercial Software)
  for GMS 3.6.2
  for GMS 3.6.0 – 3.6.1
  for GMS 3.5
  for GMS 3.4
  for GMS 3.0 – 3.3
  for GMS 2.3 64bit
  for GMS 2.0 – 2.1 64bit

• Realtime Module for HREM Filters Pro
  for GMS 3.6.2
  for GMS 3.6.0 – 3.6.1
  for GMS 3.5
  for GMS 3.4
  for GMS 3.0 – 3.3
  for GMS 2.3 64bit
  for GMS 2.0 – 2.1 64bit

• HREM Filters Lite v4.8(Free Software)
  for GMS 3.6.2
  for GMS 3.6.0 – 3.6.1
  for GMS 3.5
  for GMS 3.4
  for GMS 3.0 – 3.3
  for GMS 2.3 64bit
  for GMS 2.0 – 2.1 64bit

Required plug-ins.

• IPU plug-in (Free Software)
• HREM Mouse plug-in (Free Software)

User Key Driver

• User Key Driver / Remote Update System (RUS)

Previous versions

• HREM Filters Pro v4.6(Commercial Software)
  for GMS 3.6.0 – 3.6.1
  for GMS 3.5
  for GMS 3.4
  for GMS 3.0 – 3.3
  for GMS 2.3 64bit
  for GMS 2.0 – 2.1 64bit

• HREM Filters Lite v4.6(Free Software)
  for GMS 3.6.0 – 3.6.1
  for GMS 3.5
  for GMS 3.4
  for GMS 3.0 – 3.3
  for GMS 2.3 64bit
  for GMS 2.0 – 2.1 64bit

Archives

• HREM Filters Pro v4.4(Commercial Software)
  for GMS 2.3 (32bit)
  for GMS 2.1 (32bit) (applicable from GMS 2.0)

• HREM Filters Lite v4.4(Free Software)
  for GMS 2.3 (32bit)
  for GMS 2.1 (32bit) (applicable from GMS 2.0)

• Realtime Module for HREM Filters Pro
  for GMS 2.3 32bit
  for GMS 2.1 32bit (applicable from GMS 2.0)

• HREM Filters Pro v4.2.1(Commercial Software)
  for GMS 1.x (32bit)

• HREM Filters Lite v4.2.1(Free Software)
  for GMS 1.x (32bit)

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